OxyElite Pro Review

Oxyelite pro

OxyElite Pro recently received an upgrade!

After the FDA recalled OxyElite Pro due to safety issues (see below), USP Labs worked hard to revamp their most popular-selling diet pill.

According to advertisements, this super thermogenic formula supposedly “activates key fat burning/anti-catabolic receptors while supporting vasodilation.”

But is the new OxyElite Pro formula as effective as the old one?

Key Ingredients

OxyElite Pro’s new formula was re-released in early 2013, though many diet pill sellers are still providing outdated versions of the product.

While difficult to find an updated ingredient label, I discovered OxyElite Pro now contains the following ingredients:

Bauhinia Purpurea. Bauhinia may possess antibacterial, anti-inflammatory, and thyroid hormone-regulating activity.[1] Animal studies suggest Bauhinia may exhibit antihyperlipidemic activity as well.[2] However, additional human research needs to be conducted to verify these effects.

Aegeline. An alkaloid extract, Aegeline may boost anabolism due to its ability to convert into octopamine, a predominant metabolite. According to researchers, Aegline anabolism is likely restricted to adipocytes, potentially lowering lipid levels. However, human trials still need to be conducted.[3]

Norcoclaurine HCL . More commonly known as Higenamine, this stimulant causes tissues to tissues to contract, increasing heart rate and boosting metabolism.

According to studies, Higenamine interacts with beta-adrenergic receptors[4], which could potentially induce fat loss. But once again, these studies were conducted on animals, not humans, and like many of the ingredients in OxyElite Pro, additional research is needed.

Hemerocallis Fulva . Alcohol extracts of hemercallis increases cyclic AMP production when combined with noradrenalin.[5] This effect was minimal at best and the research was conducted on animals, not humans.

oxyelite pro supplement factsYohimbe. Yohimbe is a popular aphrodisiac commonly used to increase blood flow and alleviate depression. Studies show yohimbine, an alkaloid extract of yohimbe, decreases body fat percentage when combined with exercise.[6]

Unfortunately, yohimbine does not significantly alter body mass, muscle mass, or physical performance.

Caffeine. Caffeine blocks adenosine receptors which in turn increases wakefulness and mental acuity. When used correctly, caffeine enhances metabolism and caloric expenditure, making it easier to burn more calories than you consume.

According to researchers, caffeine doses less than 200 mg do not promote weight loss[7] (though they can increase energy). OxyElite Pro only contains 135 mg per serving. Unless you take an additional serving, the caffeine will not be strong enough to be effective.

How Is the New Formula Different?

With the exception of caffeine and bauhinia, the new OxyElite Pro formula is completely different from the original.

OxyElite Pro originally contained ingredients such as bacopa monniera, cirsium oligophyllum, and rauwolscine. These herbs were touted as amazing fat burners, and like the new formula, were largely unproven.

However, these herbs weren’t why OxyElite Pro was pulled from the shelves.

Rather, it was because OxyElite Pro contained 1,3-Dimethylamylamine, or DMAA.

DMAA is a natural stimulant extracted from geraniums. It interacts with the central nervous system, increasing norepinephrine release and enhancing metabolism.

According to the FDA, however, DMAA in large concentrations can be deadly.

On April 24, 2012, the FDA issued a warning letter to multiple diet pill manufacturers (including USP Labs) recalling several DMAA-based products.

According to the letter:

“dimethylamylamine narrows the blood vessels and arteries, which increases cardiovascular resistance and frequently leads to elevated blood pressure. This rise in blood pressure may increase the work of the heart such that it could precipitate a cardiovascular event, which could range from shortness of breath to tightening of the chest and/or a possible myocardial infarction (heart attack).” [8]

Due to this potentially lethal side effect, the FDA advised USP Labs to “immediately cease distribution” of OxyElite Pro.

Consequently, USP Labs stopped selling the product on their site until they could reformulate it. (Older versions of the product are still available through second-party distributors.)

Is It Safer?

OxyElite Pro may have been reformulated for safety, but I’m not entirely convinced that the new product is any safer than its predecessor.

As mentioned earlier, many of the ingredients in OxyElite Pro are unproven. The safety and effectiveness of many of these ingredients have not been determined.

Furthermore, OxyElite Pro still contains yohimbe, which is associated with numerous side effects such as rapid heart rate, increased blood pressure, insomnia, skin flushing, and restlessness. More severe side effects include panic attacks, hallucinations, headaches, and dizziness.

According to Phyllis Balch, CNC, the therapeutic index is fairly low and the range between an effective dose and a dangerous dose is very narrow. A few milligrams could mean the difference between effective weight loss and dangerous side effects.

Since OxyElite Pro contains unknown yohimbe concentrations, it’s unknown whether the ingredient has been used correctly.

How to Use OxyElite Pro

The new OxyElite Pro directions are much like the old one. Simply take 1 capsule on an empty stomach 15-30 minutes before breakfast.

Depending on your tolerance to the ingredients, you may take an additional capsule 5 to 6 hours later.

Interestingly enough, the label allows dieters to push safety’s boundaries even further by taking an additional capsule in the morning – for a total of 3 pills per day.

Dieters are should consume at least 125 fl. oz. of liquid per day (for men) and 91 fl. oz. (per women).

Do not take OxyElite Pro for more than 8 weeks followed by a subsequent 4 week break. Do not take more than 3 capsules in a 24 hour period.

It also warns, “under no circumstances should initial serving size be exceeded or the warnings on this bottle ignored.”

Additional precautions

• Do not use in combination with caffeine or any other stimulants (including coffee, tea, soda)
• Do not use in combination with other dietary supplements or medications
• Do not use under extreme conditions of heat, sleep deprivation, or dehydration
• Do not combine with alcohol
• Do not use if under the age of 18
• Consult your doctor if you have any pre-existing medical conditions

Where to Buy OxyElite Pro

OxyElite Pro is available for the followings prices:

• Nutraplanet.com: $29.99
• GNC.com: $59.99
• BodyBuilding.com: $39.97
• A1Supplements.com:$39.75
• VitaSupply: $45.24

Be Careful Which Formula You Buy. Some sites offering OxyElite Pro sell the old, recalled product rather than the new one. While other sites still have the old ingredient label but are actually selling the reformulated version.

When ordering OxyElite Pro, it’s best to double-check with the manufacturers that they’re selling the new and improved OxyElite Pro which doesn’t contain DMAA.

More About USP Labs

USP Labs is among the few diet pill manufacturers who offer great customer service. According to the Better Business Bureau, only 3 complaints have been filed against the company – all of which received a prompt, satisfactory response.

The manufacturers say, “we are confident that you’ll love our products. We receive a countless number of testimonials from satisfied customers every day. If for whatever reason you are not satisfied with any product bearing our name, simply return it to us with your receipt for a quick & courteous refund.”

That’s pretty impressive considering that most diet pill companies only provide returns on products purchased from the official website.

Pick It or Pitch It?

OxyElite Pro is one of the most highly recommended diet pills in the industry right now, and there are countless consumer reviews testifying that it works.

However, these reviews are primarily tied to the original formula, not the DMAA-free version. Consequently, it’s difficult to anticipate how effective OxyElite Pro will be.

The ingredients are sketchy at best, with little clinical research to validate its performance. But that doesn’t mean it won’t work for you.

As it is, I don’t feel comfortable recommending OxyElite Pro – either the old or new version. Until I have additional information confirming its safety and effectiveness, I think dieters are better off finding a more reliable supplement.

References

[1] Kumar and chandrashekar. “Bauhinia purpurea Linn.: A Review of its Ethnobotany, Phytochemical and Pharmacological Profile.” Research Journal of Medicinal Plant. 2001. Vol: 5; Is. 4; Page no: 420-431. DOI: 10.3923/rjmp.2011.420.431 Available from: http://scialert.net/abstract/?doi=rjmp.2011.420.431

[2] Kakshmi et al. “Antihyperlipidemic activity of Bauhinia purpurea extracts in hypercholesterolemic albino rats.” International Journal of PharmTech Research. Vol.3, No.3,pp 1265-1272, July-Sept 2011. Available from: http://www.sphinxsai.com/Vol.3No.3/pharm/pdf/PT=08(1265-1269)JS11.pdf

[3] SP O’Brien, “New ‘anabolic:’ Aegelin.” High Tower Pharmacology. Jan. 8, 2013. Available from: http://hightowerpharmacology.blogspot.com/2013/01/new-anabolic-aegeline.html

[4]Kimura et al. “Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria.” The Japanese Journal of Pharmacology. 1994 Sep;66(1):75-80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7861670

[5] “The extraordinary weight-loss mechanism of Hemerocallis fulva.” Available from: http://www.ergo-log.com/hemerocallisfulva.html

[6] Ostojic SM. “Yohimbine: the effects on body composition and exercise performance in soccer players.” Research in Sports Medicine. 2006 Oct-Dec;14(4):289-99. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17214405

[7] Astrup et al. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.” International Journal of Obesity. 1992 Apr;16(4):269-77. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1318281

[8] USP Labs, LLC. 4/24/12. Warning Letter.” US Food and Drug Administration. April 24, 2012. Available from: http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2012/ucm302167.htm

[9] Balch, Phyllis A. “Prescription for Nutritional Healing, fourth edition.

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